A recent study reveals that people who come off blockbuster weight-loss injections like semaglutide or tirzepatide can put back on shed pounds at a significantly accelerated pace than those who stop conventional diet and exercise plans.
Research printed in a major health publication points out that while obese people frequently drop about a fifth of their body weight while undergoing treatment, the mass is regained at an average rate of 0.8 kg per month after stopping.
"People buying these medications need to be cognizant of the risk of fast rebound weight gain when the treatment ends," warns lead investigator Dr. Susan Jebb.
That rate of recovery suggests a reversion to starting weight within about one and a half years.
Analyzing Treatments
The analysis, which reviewed dozens of trials involving thousands of participants, contrasted the effects of these new drugs with other pills.
Researchers emphasize that individuals who shed pounds through diet and exercise usually see a slower creep back—perhaps 0.1 kg a month—post-intervention.
Explaining the Quick Regain
Experts suggest the mechanism of the drugs accounts for the heightened regain.
These medications imitate a natural hormone called GLP-1, which helps regulate appetite.
"Long-term administration of GLP-1 levels far above than the body's typical production might result in the system to generate a reduced amount of its endogenous GLP-1, and may also diminish responsiveness to its effects," explained Dr. Adam Collins, a dietetics expert.
"Discontinuation of this GLP-1 'fix' means appetite is unsuppressed, making binge eating a significant risk."
A Lifelong Issue?
Health authorities recommend the jabs for people with obesity-related medical conditions, accompanied by recommended lifestyle changes.
Many experts contend that, considering the significant potential of relapse, the therapy should be considered long-term.
This view is reinforced by drug manufacturers, who state that the results "emphasize the chronic nature of obesity," akin to managing diseases like hypertension.
User Accounts
People who have come off the jabs report a powerful return of hunger.
"I experienced a switch activating and you become starving," said an individual.
The struggle is exacerbated if patients have not adopted sustainable lifestyle or habit modifications during therapy.
Widespread Adoption
Survey data suggest that a significant number of people in the UK have used weight-loss jabs in the past year, with interest being substantial.
- Adoption is more common among women than men.
- The 40s and 50s age group shows the greatest usage rates.
- A large proportion obtain the drugs through private healthcare rather than the NHS.
Finally, clinicians stress that while these medications are powerful tools for shedding pounds, they are not a magic solution and lasting health benefits likely depends on combined behavioural changes.
